Killing of pathogens

Figure 17.24 Activation of C3 convertase and effects of activation. There are three pathways that activate complement and four mechanisms that facilitate the killing of pathogens (see text). C3 is the convertase enzyme.

Chronic granulomatous disease Killing of pathogens affected... 

This is probably due to a reduction of the peak concentration of the drug in the cardiac tissue, the organ most severely affected by doxorubicin upon injection. Release of drug from the Kupffer cells upon breakdown of the nanoparticles in the lysosomal system (see Figure 5.2) may induce a slow release pattern that is still tumoricidal, but does not evoke the cardiotoxic effects. Another application where these nanoparticles have been shown to have large therapeutic promise is the killing of pathogens that are specifically located in the Kupffer cells in the liver. 

Anes E, KuKnel MP, Bos E cc al. Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nat Cell Biol 2003 5(9) 793-802. 

Involvement in pathogen-induced cell necrosis and in killing of pathogens via direct oxygenation of membranes ( )... 

In every case, disinfection means the killing of pathogens. This can be accomphshed either by the destruction or the modification of some of their cell components (i.e., destruction of the cellular membranes, modification of nucleic acids, etc.). 

Temperature and time are two parameters responsible for the effects of a thermal treatment. They should be selected carefully to make sure that all necessary changes, e. g., killing of pathogens, are guaranteed, but still all undesired changes such as degradation of vitamins are kept as low as possible. 

Control of Microorganisms. Treatment-regime tests with Ca(OCl)2 and chloroisocyanurates killed all pathogenic bacteria, including the... 

Leucocidins kill leucocytes and are produced by many strains of streptococci, most strains of Staphylococcus aureus and likewise most strains of pathogenic Gram-negative bacteria, isolated from sites of infection. 

Initially, the tank is charged with 25% of its volume with water and the appropriate amount of sanitiser. Products are introduced by adding a water-soluble sachet containing liquid or powder sanitisers or by adding a liquid product directly from a plastic bottle prefilled with the correct amount. This procedure accurately controls dosage rates and limits worker exposure. Products are diluted more than 400 times and are required to kill all pathogens within 15 minutes. 

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