Kiihni extractor

Solvent extraction of penicillin from fermentation broths has been well documented in the literature. Penicillin G and penicillin V can be efficiently extracted with amyl acetate or butyl acetate at pH 2.5-3.0 and at 0° to 3°C.33 Schiigerl1 systematically reviewed solvent extraction of different forms of penicillin from fermentation broths. Figure 1 shows an integrated process for the extraction of penicillin G from clarified broth of Penicillium chryso-genurn fermentation.1 Penicillin G is converted to 6-amino penicillanic acid and phenylacetic acid at pH 8 in a 10 L Kiihni extractor by penicillin G-amidase immobilized in an emulsion liquid membrane. The 6-amino penicillanic acid is subsequently converted to ampicillin at pH 6 and the enzyme is recycled. 

Advances in development resulted in the Oldshue-Rushton and Kiihni extractors [43, 45]. The Kiihni extractor has shrouded turbine impellers for agitation to promote radial discharge characteristies (Fig. 2.19). The stator discs are made from perforated plates and the residence time can be varied by changing the distance and the hole diameter of these plates. These extractors can be used in the dispersion or mixer-settler mode. Therefore, they can be adapted to extreme phase ratios and reach high... 

Rotating-Impeller Columns A number of different rotating-impeller column extractors have been proposed and built over the years. Only the Scheibel and Kiihni designs are reviewed here. For information about the Oldshue-Rushton design, see the previous edition of this handbook. Also see Oldshue, Chap. 13.4 in Handbook of... 

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