Kidney storage solutions

The usual kidney storage solutions use an imperme-ant solute, such as phosphate, lactobionate, glucose, sucrose or raffinose. There is less agreement about the need for other minor components used to minimize acidosis or oxidative reperfusion injury, or enhance regeneration following revascularization. At present, the best known solutions are University of Wisconsin (UW), histidine-tryptophan ketoglu-tarate (HTK, Custodiol ) or Celsior . 

Answer Unlike water-soluble compounds, lipid-soluble compounds are not readily mobilized— that is, they do not readily pass into aqueous solution. The body s lipids provide a reservoir for storage of lipid-soluble vitamins. Water-soluble vitamins cannot be stored and are rapidly removed from the blood by the kidneys. 

A number of studies have highlighted the degradation of residues during frozen storage, including P-lactam antibiotics in milk ampicillin in pig muscle chlortetracycline in incurred pig muscle, liver, and kidney " sulfamethazine in incurred pig muscle and bovine milk and gentamicin residues in egg. The EU validation criteria require that stability be determined for the analytes in matrix and in solution at various stages of the sample preparation process. Preferably, incurred tissue should be used otherwise... 

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