KHARASH-SOSNOVSKY Allylic Oxidation

KHARASH - SOSNOVSKY Allylic oxidation 202 KILIANI FISCHER Sugar homologation 203 Kim 79 Kinnear 67 Kindler 416... [Pg.225]

Oxidations. A widely used method for allylic oxidation is the Kharash-Sosnovsky reaction using a peroxide and a copper(I) salt system. Enantioselective allylic oxidations of cycloalkenes such as cyclopentene, cyclohexene and cycloheptene with tert-butyl peibenzoate were investigated with a variety of catalysts derived from bis(oxazoline) ligands and copper(I) triflate complexes (eq 18). The ligand-copper(I) complexes from the /-Bu-... [Pg.112]

Several methods are now available for allylic oxidation. Among them, the ene-type oxidation reaction with, e.g., Se02 or 02 oxidation have been the most widely used for the purpose [15] but their asymmetrization has not met with success. Another widely used method is the Kharash-Sosnovsky reaction using a peroxide and Cu(I) salt system [16]. This reaction has been considered to proceed through a Cu(III)-allyl complex 7 (Scheme 6) [17]. [Pg.757]

KHARASH-SOSNOVSKY AllylicOxidation Cu catalyzed allylic or propargylic oxidation with t-butyl peresters (see 1st edition). [Pg.195]

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