Ketones reduction using amino acid anions

Reduction of ketones using amino acid anions as catalyst and hydrosilane as oxidant... 

REDUCTION OF KETONES USING AMINO ACID ANIONS AS CATALYST AND HYDROSILANE AS OXIDANT... 

One of the fundamental operations in organic synthesis remains the stereoselective reduction of carbonyl groups1241. In a process related to that reported by Hosomi et u/.[25], using hydrosilanes as the stoichiometric oxidant and amino acid anions as the catalytic source of chirality, a variety of ketones were reduced in good to excellent yield and with good stereoselectivity1261. This process reduces the amount of chiral catalyst needed and utilizes catalysts from the chiral pool that can be used directly in their commercially available form. 

Table 11.9 Reduction of Ketones Using HSi(OEt)3 and amino acid anions.

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