KCNH2 potassium channel

Anson BD, Ackerman MJ, Tester DJ, Will ML, Delisle BP, CL Anderson BP, January CT. Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am J Physiol Heart Circ Physiol 2004 286 H2434-H2441. 

Paavonen KJ, Chapman H, Laitinen PJ, Fodstad H, Piippo K, Swan H, Toivo-nen L, Yiitasalo M, Kontula K, Pasternack M. Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG). Cardiovasc Res 2003 59 603-611. 

HERG potassium channel (KCNH2) that has been found to modulate quinidine and/or cisapride safety in clinical practice as well as KvLQTl potassium channel (KCNQl) that causes a similar effect on terfenadine and disopyramide response [28,29]. 

The KCNQl and KCNH2 genes code for two major cardiac repolarizing currents, and mutations in these channels have been shown to cause long QT syndrome (LQTS) type 1 and type 2, respectively (Modell and Lehmann, 2006). iPSC-CMs carrying mutations in these cardiac potassium channels... 

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