Katchalski-Katzir method

The Katchalski-Katzir method is a grid based approach to evaluate the shape complementarity between two proteins (see Figure 8.3). Consider two mol-... 

Katchalski-Katzir E., Haas E. and Steinberg I. A. (1981) Study of Conformation and Mobility of Polypeptides in Solution by a Novel Fluorescence Method, Ann. N.Y. Acad. Sci. 36, 44-61. 

Solomon B, Hollander Z, Koppel R, Katchalski-Katzir E (1987) Methods Enzymol 135 160... 

Advances in the understanding of structure-activity/selectivity relations for enzymes evolving from the use of x-ray, NMR, and other instrumental methods for characterization of enzyme structures should contribute to the development of improved immobilized enzyme systems for both analytical and industrial applications. Immobilized enzyme technology has enormous potential, but significant advances on several fronts are necessary prior to widespread industrial use of this technology. Katchalski-Katzir has discussed this problem in a review of past successes and failures in efforts to employ immobilized enzymes in the food, pharmaceutical, and chemicals industries. ... 

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