K.562 leukemia cells

Later, a series of azuleneindoles 237 and 240 were synthesized by Hong and coworkers [60] by the microwave-assisted [6-1-4] cycloaddition of fulvenes 22 and 238 with various a-pyrones (236 and 239). Some of the azuleneindoles display potent antineoplastic activities (Scheme 7.54). For example, an azuleneindol was found to be a potent and selective growth inhibitor of the K-562 leukemia cell line with IC50 of 0.51 mM. 

---