Josef Rudinger

Academy of Science. Rudinger headed the Laboratory of Peptide Chemistry until 1968, when with his wife Edita Adler, herself a chemist, and their 9 year old daughter, he emigrated to Switzerland. They found a new home in Zurich and Rudinger was appointed Professor in the Institute of Molecular Biology and Biophysics of the ETH, an appointment that was terminated by his untimely death in 1975. 

We can not enumerate here Rudinger s many valuable contributions to the methodology of peptide synthesis or to the design of molecules for specific pharmacological studies. It seems to be more important to recall one of his ideas, that had and still has a major impact on peptide chemistry. In 1958 he invited the 

While he was among us, Rudinger represented a spirit of dedication, cooperation and integrity. His legacy remains a major asset for all whose life is enriched by a sincere interest in peptides. 

CrystaUine insulin was well suited for chemical investigations and it soon became clear [88-90] that the hormone is built of amino acids, that it is a peptide. The importance of the disulfide bridges was clarified not much later [91] and the role of molecular architecture in the hormonal activity of insulin postulated in the late thirties [92]. 

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In this Introduction, references not given specifically are eontained, prior to 1972, in Meienhofer s review (4), prior to 1989 in Solid Phase Peptide Synthesis. A Practical Approach (5), and prior to 1993 in the European Peptide Symposium Josef Rudinger Lecture (6). Reference 5 gives a general survey of the development of Fmoc-based soUd phase synthesis up to 1989. 

Rudinger, Josef (1924—1975), a noted peptide chemist and founder of the European Peptide Symposia, together with Geoffrey Young, starting in Prague in 1958. He was born in Jerusalem, educated in Czechoslovakia and England, and in 1949 returned to... 

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