Jencks postulate

Jencks postulate says that antibodies generated against an organic molecule resembling the transition state of a given reaction should catalyze this process. 

Quantitative expressions of the Hammond postulate may be derived from these parameters (Miller, 1959 Cordes and Jencks, 1962 Jencks, 1969a). Thus, for example, combination of the Hammett and Br nsted eqns (8) and (9) respectively, for a series of i substrates reacting with j general acid catalysts leads to (10). 

Short reference will be made to the decomposition of benzylazoxy-4-toluenesulfo-nate (7.21) studied by Maskill s group (Maskill, 1980 Maskill and Jencks, 1984,1987 Conner and Maskill, 1988 Gordon and Maskill, 1989, and further papers mentioned there). As shown in (7-9), this reaction also leads to solvolysis products of car-bocations, but with nitrous oxide as a leaving group rather than an N2 molecule. The intermediacy of an alkoxydiazonium ion (7.22) is postulated on the observation that considerable amounts of benzyl thiocyanate (7.23) and some benzaldehyde... 

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