JAPP-KLINGEMANN Hydrazone Synthesis

Hydrazones from a-ketoesters and diazonium salts with the acid of base. 

Name Reactions, 4th ed., DOI 10.1007/978-3-642-01053-8 133, Springer-Verlag Berlin Heidelberg 2009 

Japp-Klingemann hydrazone synthesis. In Name Reactions for Functional Group Transformations, Li, J. J., Corey, E. J., eds. John WUey Sons Hoboken, NJ, 2007, pp 630-634. (Review). 

Name Reactions A Collection of Detailed Mechanisms and Synthetic Applications, DOI 10.1007/978-3-319-03979-4 142, Springer International Publishing Switzerland 2014 

Frohberg, P. Schulze, L Dormer, C. Krauth, F. Tetrahedron Lett. 2013, 53, 4507 509. 

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JAPP KLINGEMANN Hydrazone Synthesis Synthesis ot hydrazones trom diazonum saKs and an activated methylene group (or enamlne)... 

JAPP Oxazole synthesis 187 JAPP KLINGEMANN Hydrazone synthesis 188 JAROUSSE MAKOSZA Phase transler 189 JEGERTetrahyikoturan synthesis 190 JOHNSON Phenol aHcynylation 191 Johnson 168,197,240 JONES Oxidation reagent 192 JULIA BRUYLANTS Cyclopropyl earbinol rearrangement 193... 

A better understanding of this mechanism aids our appreciation of how the reaction works, and helps us design novel reactions. The Japp-Klingemann hydrazone synthesis is sueh an example. A hydrazone is an... 

J. Li (2007) Japp-Klingemann hydrazone synthesis, in Name Reactions for Eunctional Group Transformations (eds. J.J. Li and E.J. Corey), Wiley Sons, Hoboken, New Jersey, pp. 630-634. 

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