Janolus cristatus

The neurotoxic lipophilic tripeptide, janolusimide (112), was isolated from the Mediterranean nudibranch Janolus cristatus. The structure was determined by spectroscopic and classical chemical methods [181] and confirmed by synthesis [182]. It has been suggested that the pyrrolidine-2,4-dione may arise from condensation of valine and isobutyrate [181]. 

A lipophilic tripeptide, janolusimide (342), was isolated from the Mediterranean nudibranch Janolus cristatus and was found to be toxic to mice (260). From the Swedish sponge Geodia baretti barettin, a cyclic polypeptide, was isolated and found to show inhibiting activity on electrically induced contractions of isolated guinea pig ileum (261). Barettin is composed of dehydro-6-bromotryptophan and proline. The initial proposed... 

Sodano, G. and Spinella, A. (1986) Janolusimide, a lipophilic tripeptide toxin from the nudibranch mollusc Janolus cristatus. Tetrahedron Lett., 27,2505-2508. 

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