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Izonsteride

This product is then treated with acryloyl chloride. The initial step in this case probably involves the acylation of nitrogen on the enamine conjugate addition then completes the formation of the lactam ring (23-5). Treatment of that product with triethyl silane then reduces the ring unsaturation and cleaves the benzylic nitrogen bond on the auxiliary to yield (23-6) as the optically pure tmns isomer. Displacement of bromine with the mercapto benzthiazole (23-7) completes the synthesis of izonsteride (23-8) [25]. [Pg.209]


See other pages where Izonsteride is mentioned: [Pg.672]    [Pg.223]    [Pg.241]    [Pg.258]    [Pg.672]    [Pg.223]    [Pg.241]    [Pg.258]   
See also in sourсe #XX -- [ Pg.209 ]

See also in sourсe #XX -- [ Pg.223 ]




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