Isozymes, lipoamide dehydrogenase

Lipoamide dehydrogenase has been isolated from many species and these are listed in Table II (4, S6, 90-115). The mammalian enzymes are of mitochondrial origin. Where tested, the enzyme from eukaryotic sources is isozymic, while that from prokaryotes is a single species (105). There are marked differences in the sensitivity of the enzyme as isolated from various sources to inhibition by excess NADH in the NADH -> lipSaNH reaction and in the relief of that inhibition by NAD+ (27, 99, 105, 106, 108, 109, 116, 117). Attempts to make phylogenetic... 

---