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Pharmaceutically interesting isothiazoles

The reaction of (148) with glycol and hydrogen peroxide gave (149). Compound (19b) has been reduced with liAlH4 to the corresponding alcohol, which was converted into the aldehyde and bromomethyl and aminomethyl derivatives that are of pharmaceutical interest. A mild method for the hydrolysis and decarboxylation of various amides of methyl 3-aminothiophen-2-carboxylates has been developed. Thermal decomposition of (150) led to cleavage of the thiophen ring, with extrusion of sulphur and formation of the isothiazole (151). ... [Pg.101]

See other pages where Pharmaceutically interesting isothiazoles is mentioned: [Pg.270]    [Pg.244]    [Pg.253]    [Pg.270]    [Pg.216]    [Pg.295]    [Pg.295]    [Pg.179]    [Pg.180]   
See also in sourсe #XX -- [ Pg.295 ]

See also in sourсe #XX -- [ Pg.295 ]



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Isothiazole

Isothiazoles

Pharmaceutical interest

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