3 -Isoquinolinones, 5,6,7,8-tetrahydro

Solid-phase syntheses have become increasingly popular during the period of this review, with examples including the synthesis of 5,6,7,8-tetrahydro[l,6]naphthyridines from Meldrum s acids derived from /3-amino alcohols via Hantzsch condensation and cyclization with cyclative cleavage from the resin (using 70% trifluoroacetic acid (TFA)/dichloromethane (DCM) followed by 5% triethylamine/DCM) <1999S1951> and also of isoquinolinones and 5-oxo-5,6-dihydro-[l,6]naphthyridines <1995JOC5748>. 

As discussed previously (Section II,C,2), a great number of 1-aryl-3(2//)-isoquinolinones furnish 5,6,7,8-tetrahydro-3(2//)-isoquinolinones... 

Indole Iodide Isocyanide Isoquinoline (dihydro) (tetrahydro) Isoquinolinone Isoxazole P-Keto ester Ketone... 

Suginome, H., Kajizuka, Y., Suzuki, M., Senboku., H., and Kobayashi, K., Photoinduced molecular transformations. 147. [2 -I- 2] Photoaddition of protected 4-hydroxy-l(2fd)-isoquinolinone with an electron-deficient alkene and the formation of a 3,6-epoxy-3,4,5,6-tetrahydro-2-benzazocin-l(2H)-one via a P-scission of cyclobutanoxyl radicals generated from the resulting photoadduct. Heterocycles, 37, 283, 1994. 

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