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Isoquinoline aldol cyclization

The Pictet-Spengler condensation has been of vital importance in the synthesis of numerous P-carboline and isoquinoline compounds in addition to its use in the formation of alkaloid natural products of complex structure. A tandem retro-aldol and Pictet-Spengler sequence was utilized in a concise and enantioselective synthesis of 18-pseudoyohimbone. Amine 49 cyclized under acidic conditions to give the condensation product 50 in good yield. Deprotection of the ketone produced the indole alkaloid 51. [Pg.476]

See other pages where Isoquinoline aldol cyclization is mentioned: [Pg.234]   
See also in sourсe #XX -- [ Pg.2 , Pg.173 ]

See also in sourсe #XX -- [ Pg.173 ]

See also in sourсe #XX -- [ Pg.2 , Pg.173 ]

See also in sourсe #XX -- [ Pg.173 ]



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Aldol cyclizations

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