2,3-Isopropylidene-L-erythrose

Stork and Raucher [76] have reported a chiral synthesis of PGA2 starting from 2,3-isopropylidene-L-erythrose from which they prepared the intermediate (85). Cyclisation with potassium t-butoxide in tetrahydrofuran and alkaline hydrolysis then afforded the keto acid (86a) which was transformed into PGA2 via reaction with lithium diisopropylamide and then phenyl selenyl chloride, oxidation of the product (86b) with sodium periodate and removal of the ethoxyethyl group. 

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