Isopropylamine hydrochloride

Three liters of anhydrous ether were added thereto and the N-[/3-(o-chlorophenyl)-/3-hy-droxyethyl] -isopropylamine hydrochloride precipitated in crystalline form as the monohydrate. The mixture was maintained at about 0°C for 40 hours and then filtered. The filter cake was washed with ether and dried. About 209 g of N-[/3-(o-chlorophenyl)-/3-(hy-droxy)-ethyl] isopropylamine hydrochloride monohydrate, melting at about 163° to 164°C, were obtained according to U.S. Patent 2,816,059. 

After filtration of the isopropylamine hydrochloride and bromohydrate, the solvent is stripped and the residue is admixed with 4 N HCI and the aqueous phase is washed with ether. The aqueous phase is treated with 50% aqueous NaOH, the amine is ether-extracted and, after drying on anhydrous Na2S04, the ether is distilled and the residue is rectified in vacuum to obtain 14 g of the product. Yield = 50%. 

P-HYDROXY-P-(2,5-DIMETHOXYPHENYL)-ISOPROPYLAMINE HYDROCHLORIDE see MDWOOO HYDROXYDIMETHYLARSINE OXIDE see HKCOOO HYDROXYDIMETHYLARSINE OXIDE, SODIUM SALT see HKC500... 

Dimethoxyphenyl)-, -( -phenylethji)isopropylamine Hydrochloride Typical Procedure1R ... 

Isopropylsulfamoyl chloride can be obtained at a good yield by the reaction of isopropylamine hydrochloride with sulfuryl chloride in the presence of a Lewis acid catalyst (SbCIj) in acetonitrile as solvent (Weiss and Schulze, 1964). 

This method was first applied by Weisbalt 135) to the synthesis of ethyl a-hydroxyamino-a-carboethoxy-P-(3-indole)-propionate. The reduction of nitrohydantoins (72) with zinc dust in the presence of ammonium chloride 136,137) or isopropylamine hydrochloride (97) was the basis for the first syntheses of N -hydroxyomithine (73) and N -hydroxylysine (74), but gave only low yields (Scheme 20). Further attempts at synthesis of N -hydroxyornithine (73) 138) and N -hyd-roxylysine (74) 139) based on such reductions were unsuccessful. The conditions for reduction of nitroester (75) to the ester of N-hydroxy-amino acid (76) were investigated by CfflMiAK 80), who obtained (78, 79) in aqueous methanol solution. Shin 140) also reduced nitro-esters (75) to (76, 77) using aluminium amalgam (Scheme 21). 

Isopropylamine hydrochloride 2-Propanamine hydrochloride CjHijCIN 16672-66-2 96.671 164 sDMSO... 

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