Isoindole from

Phthalazine-1,4-diones reactions, 3, 39 Phthalazines applications, 3, 56 isoindoles from, 4, 152 mass spectra, 2, 21 metabolism, 1, 233 N-oxidation, 3, 20 nitration, 3, 22 nucleophilic attack, 3, 25 oxidation, 3, 31... 

Isocyanine, hydride ion transfer in, 43 Isoindoles, from 5-hydroxy-THlSs, 9 Isothiocyanates, adducts with thiazolium salts, 35... 

Scheme 44 Attempted synthesis of isoindoles from mononitro-substituted aromatic compounds...

Scheme 45 Synthesis of benzo-fused isoindoles from dinitronaphthalenes...

Formation of diastereomeric N-alkyl-2- S-(lA-acetyl-L-cystem))-y isoindoles from o-phthalaldehyde/H-acetyl-t-cysieine OPT/AcCys)... 

Formation of diastereomeric isoindoles from o-phlhaldialdehyde and chiral thiols... 

HCl bubbled through N-ethyl-N-allylfurfurylamine in ether, a soln. of the resulting hydrochloride in ca. 3 M HCl heated at 90° for 3 h, and neutralized with NaHCO, N-ethyl-l,2-dihydroisoindoline. Y 75-85%. The intermediate can be isolated if required. F.e.s. J.E. Hernandez et al., Synth. Commun, 18, 2055-61 (1988) in situ-generation of isoindoles from N-propargyl derivs. s. A.R. Katritzky et al., J. Heterocyc. Chem. 26, 421-6 (1989). 

H)-Dioxo-5H-pyrrolo [2,1 - a] isoindoles from y-phthalimido-) -ketocarb-oxylic acid esters s. 18,987 2,6-dioxo-2,3,4,6-tetrahydropyrido[2,l-a]isoindoles s. M. Viscontini, W. Kaiser, and H. A. Leidner, Helv. A8, 1221 (1965)... 

Donepazil is a reasonably potent D4 dopamine receptor inverse agonist (/targeted compounds with improved D2 potency, while maintaining suitable properties for CNS activity. This resulted in a series of isoindoles from which eight compounds were synthesized and tested, leading to measured D2 receptor affinities between 156 and 1700 nM. These included compound 3, shown in Figure 15.9, which was also shown to penetrate the brain in vivo. 

Acetic anhydride-triethylamine Isoindoles from isoindoline N-oxides s. 20, 648a suppl. 29... 

Isoindoles from cyclic quaternary hydrazinium salts s. 27, 449 <-... 

Scheme 7.17 One-pot synthesis of pyrazolo[5,l-a]isoindoles from l-(2-bromophenyl) buta-2,3-dien-l-one, hydrazine hydrate, and isocyanide...

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