Isocitrate lyase, function

Fig. 2. (A) The glyoxylate cycle as a bypass of the TCA cycle (after Komberg and Krebs, 1957). (B) The glyoxylate cycle as it functions in the glyoxysome, showing the production of succinate from 2 mol of acetyl-CoA. The five steps constituting the cycle are catalyzed by the following enzymes (1) citrate synthetase, (2) aconitase, (3) isocitrate lyase, (4) malate synthetase, (5) malate dehydrogenase.

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