Isochromophilones III

Arai N, Shiomi K, Tomoda H, Tabata N, Yang DJ, Masuma R, Kawakubo T, Omura S (1995) Isochromophilones III VI, Inhibitors of Acyl-CoA Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216. J Antibiot 48 696... 

New azaphilones named isochromophilones III-VI (18-21) were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of ACAT. Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones (17-20) (ACAT) activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 pM, respectively [79]. 

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