Levodopa Isocarboxazid

Adrenaline, apomorphine, ascorbic acid, benserazide, dihydralazine, dobutamine, dodecyl gallate, dopamine, ethylnoradren-aline, hexoprenaline, hydralazine, iproniazid, isocarboxazid, isoetharine, isoniazid, isoprenaline, levodopa, meban-azine, methyldopa, methyldopate, nialamide, noradrenaline, phenelzine, procarbazine, protokylol, rimiterol... 

SELECTIVE MAO-B INHIBITORS Two isozymes of MAO (MAO-A and MAO-B) oxidize monoamines and both are present in the periphery and GI tract MAO-B is the predominant form in the striatum and is responsible for most of the oxidative metabolism of dopamine in the brain. At low-to-moderate doses (10 mg/day or less), selegiline (eldepryl) selectively and irreversibly inhibits MAO-B. Unlike nonspecific inhibitors of MAO (e.g., phenelzine, tranylcypromine, isocarboxazid), selegiline does not inhibit peripheral metabolism of catecholamines and can be taken safely with levodopa. Selegihne does not cause the lethal potentiation of indirectly acting sympathomimetic amines such as dietary tyramine. Doses of selegiline higher than 10 mg daily can produce inhibition of MAO-A and should be avoided. 

Similar cases of severe, acute hypertension, accompanied in most instances by flushing, throbbing and pounding in the head, neck and chest, and light-headedness have been described in other case reports and studies involving the concurrent use of levodopa with pargyline, nialamide, tranylcypromine, phenelzine and isocarboxazid. ... 

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