3- isobutyl-6- pyrazinone

Such substrates are seldom used but tert-butyl (I - I -W-methoxy-A-methylcar-bamoyl)-3-methylbutyl]carbamoyl -2-phenylethyl aminoformate (44) gave 3-ben-zyl-6-isobutyl-2(l//)-pyrazinone (45) (21%) by two deprotections (LiAlH4 and HC1—dioxane) and a final cyclization in acetonitrile during 13 h.1510... [Pg.9]

Methylthioethyl)-5-phenyl-2(l//)-pyrazinone (20) gave 2-chloro-3-(2-methylthioethyl)-5-phenylpyrazine (21) (COCl2, PhMe—THF, reflux, 4 h >95%) 315 2-chloro-3-isobutyl-5-phenylpyrazine (>80%) similarly.632... [Pg.140]

Chloro-3-isobutyl-6-isopropylpyrazine 1-oxide (109) gave l-hydroxy-3-isobutyl-6-isopropyl-2(l//)-pyrazinone (110) (KOH, H20—MeOH, reflux, 2 h 84%) 92 homologues likewise.1250... [Pg.158]

Chloro-3-isobutylpyrazine 4-oxide gave 3-isobutyl-2( I // )-pyrazinone 4-oxide (111, R = Hu ) (5 M NaOH, reflux, 2 h 39%) 86 2-chloro-3-phenylpyrazine 4-oxide gave 3-phenyl-2( I //(-pyrazinone 4-oxide (111, R = Ph) (KOH, H20—EtOH, reflux, 1 h 30%) 1290 also analogues likewise.1290... [Pg.158]

Acetoxy-6-acetoxymethyl-3-isobutyl-5-methoxypyrazine (130) gave 6-hydrox-ymcthyl-3-isobutyl-5-methoxy-2(l//)-pyrazinone (131) (K2C03, MeOH—H20, 20°C, 30 min 97% note hydrolysis of both nuclear and extranuclear acetoxy groupings).329... [Pg.211]

Amperozide, 4-[4,4-bis(p-fluorophenyl)butyl]-A, -ethyl-1 -piperazinecarboxamide, analgesic and tranquilizer [75558-90-6],1711 Arglecin (H 7), 6-(3-guanidinopropyl)-3-isobutyl-2(l//)-pyrazinone, a Strepto-myces sp metabolite [34098-41-4].295... [Pg.241]

Mutaaspergillic acid (H 66), l-hydroxy-6-(l -hydroxy-1 -methylethyl)-3-isobutyl-2(l/7)-pyrazinone, an Aspergillus sp metabolite [15272-17-0],... [Pg.242]

Benzyl-3-isobutyl-5-methyl-2(177)-pyrazinone 3-Bonzyl-6-isobutyl-2n //)-pyrazinono 6-Benzyl-3-isopropyl-5-methyl-2( 1 //)-pyra/iiione... [Pg.372]

Benzyloxy-6-hydroxymethyl-3-isobutylpyrazine 4-oxide 2-Benzyloxy-6-iodomethyl-3-isobutyl-5-methoxypyrazine 4-oxide 2-Benzyloxy-3-isobutyl-6-mesyloxy-methyl-5-methoxypyrazine-4-oxide 1 - Benzyloxy-3 - (2-methoxycarbonyl-ethyl)-5,6-dimethyl-2(l/7)-pyrazinone... [Pg.373]

Chloro-5-isobutylpyrazine 6-Chloro-5-isobutyl-2-pyrazinecarbothioamide 6-Chloro-5-isobutyl-2-pyrazinecarboxamide 2-Chloro-3-isobutylpyrazine 4-oxide 2-Chloro-5-isopentyl-3,6-dimethylpyrazine 2-Chloro-3-isopropenyl-6-isopropyl-5-methoxypyrazine 5-Chloro-6-isopropenyl-3-isopropyl-l-methyl-2(177)-pyrazinone... [Pg.390]

Hydrazino-5,6-diphenyl-2(l//)-pyrazinone 2-Hydrazino-3-isobutyl-5-phenylpyrazine 2-Hydrazino-5-methyl-3-propylpyrazine... [Pg.425]

Isobutyl-6-isopropyl-2(17/)-pyrazinone 6-Isobutyl-3-isopropyl-2(17/)-pyrazinone 2-Isobutyl-3-methoxy-5,6-dimethylpyrazine 2-Isobutyl-3-methoxy-5-(2-methy]prop-1 -enyl)pyrazine... [Pg.433]

Isobutyl-1 -methyl-20 //)-pyrazinone 3-Isobutyl-5-methyl-2(17/)-pyrazinone 3-Isobutyl-6-methyl-2(17/)-pyrazinone 6-Isobutyl-3-methyl-2(17/)-pyrazinone 6-Isobutyl-5-methyl-2(17/)-pyrazinone... [Pg.433]

Isobutyl-2(17/)-pyrazinone 4-oxide 3-Isobutyl-2(17/)-pyrazinone 4-oxide... [Pg.433]

Amino-iV-(l-chloroacetyl-3-metliylbutyl)butyrainide (25, R = H), prepared in situ as hydrochloride by treatment of its A-tert-butoxycarbonyl derivative (25, R = CO2BU ) in HCl-dioxane, gave 3-ethyl-6-isobutyl-5-methyl-2(l7/)-pyrazinone (26) (MeOH, reflux, 2 h 90%) many analogues were made similarly. - "- -1 ... [Pg.6]

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