Ischemia/reperfusion INDEX

As shown by Alarcon de la Lastra et al. [100] using a model of gastric injury induced by ischemia-reperfusion in rats, pretreatment with silymarin, the hepatoprotective principle of Silybum marianum L. prevented post-ischemic injury. These protective effects were specifically related to reduction of MPO activity as index of polymorphonuclear leukocyte infiltration after injury. These findings indicated that inhibitory effects of silymarin on neutrophil function seem to contribute significantly to its gastroprotective actions. 

Figure 1. The original demonstration of preconditioning in open-chest dogs. Control dogs received 40 min of coronary artery occlusion plus 4 days reperfusion. In preconditioned animals the 40 min index ischemia was preceded by 4 cycles of 5-min coronary occlusion/5-min reperfusion. This caused a dramatic reduction in the percent of the ischemic tissue that infarcted. Open symbols represent individual hearts while the solid symbol shows the group mean and SEM. Adapted from Cohen.10...

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