Ischemia during aging

In addition, there is experimental evidence showing that mitochondrial cardiolipin content markedly decreases following ischemia and reperfusion injury due to cardiolipin peroxidation (Soussi et al., 1990) and that a decrease in the mitochondrial phospholipid cardiolipin occurred in aged rat hearts (Pepe, 2000). These decreases may he attrihutahle to the hydroperoxide-formation of cardiolipin after exposure to intense or repeated oxidative stress during disease state or normal aging, respectively. 

Fig. 4.10 Secondary energy failure is a phenomenon that occurs during reperfusion after 2 h of ischemia when the CBF is essentially normal and the glucose levels me at or above control The left two panels represent ATP and P-creatine levels in the adult rate, whereas the right panels indicate changes in the aging brain. Note that the core values were not presented, since SEE occured independent of age. The time course for the penumbra is indicated by the dotted lines which do not show SEP over the 8 h reperfusion time-course following 2 h of ischemia even in the core...

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 18 to 20% of the population over age 75 (7,2). By the late fifth decade almost 8% demonstrate significant asymptomatic disease on noninvasive testing, whereas 5% have symptoms of intermittent claudication, which is a major manifestation (3). This is caused by muscle ischemia secondary to inadequate blood flow that is unable to meet oxygen demands during exercise. Intermittent claudication can lead to moderate to severe impairment in the patient s walking ability. 

Drug overdose Hagigat, which contains 200 mg of cathinone (one of the components of khat leaves), approximately equivalent to 555 g of khat, are marketed in Israel in capsules as a natural stimulant. Reports to Israel s poison control center of exposure to hagigat have been analysed [61 ]. During the 10-month data collection period, there were 34 reports about patients aged 16-54 (median 25) years, 24 men and 10 women. In two cases the drug was inhaled. Myocardial ischemia was... 

---