Isatin and 3-Indazolinone

We now turn to isatin (X = NH, Y = Z = CO) (IX), where we choose the contemporary measurement [44] rather than one that is a century old [45] (as cited in [46]), and to 3-indazolinone (X = Y = NH, Z = CO) (XXIV) (again from [37] rather than from [47]). Analysis of the energetics of the formal reactions  

However, let us make estimates. We will assume that the enthalpy of formation of CH3COCONHCH3 is theaverageof those of CH3COCOCH3 andCH3NHCOCONHCH3 and approximate that of the latter by assuming thermoneutrality for reaction 17  

In this reaction we have used the value -357 kJ mol 1 for the enthalpy of formation of CH3COCONH2. This value was estimated assuming thermoneutrality for reaction 18 and using the archival value for the enthalpy of formation of the a-diketone and that of the diamide from [48]  

For 3-indazolinone (XXIV) it is necessary to estimate the enthalpy of formation of CH3CONHNHCH3. A value of -130 kJ mol 1 is obtained if we assume thermoneutrality for the next reaction (using a value from [49] for the enthalpy of formation of CH3CONHCH3)  

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