Iron-sulfur clusters regulation role

Hail DJ, Rouaoult TA, Tang CK, Chin J, Harford JB, Klausner RD (1992) Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein role of the iron-sulfur cluster. Proc Natl Acad Sci USA 89 7536-7540... 

From One Type to Another Type of Fe-S Cluster. Iron-sulfur clusters, such as [2Fe-2S], [3Fe-4S], and [4Fe-4S], are found in proteins see Iron-Sulfur Proteins). One of the most interesting aspects of the iron-sulfur proteins is their ready conversion from one type to another through chemical oxidation and reduction, pH changes, or site-directed mutagenesis.More importantly, several studies have indicated that some of the cluster conversions are physiologically relevant in that they play important roles in regulation of enzyme activity. 

Tong, W.-H., Rouault, T.A. (2007). Metabolic regulation of citrate and iron by aconitases role of iron-sulfur cluster biogenesis. BioMetals 20 549-64. 

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