Penicillamine iron salts

Iron salts Penicillamine 1 The absorption of penicillamine is decreased by 35% with coadministration of iron salts. 

Drugs that may affect penicillamine include gold therapy, antimalarial or cytotoxic drugs, iron salts, antacids, and food. 

Penicillamine (D-(3,(3-dimethylcysteine) is an effective chelator of copper, mercury, zinc and lead which promotes the excretion of these metals in the urine. It is clinically used in patients with Wilson s disease, with rheumatoid arthritis and with heavy-metal intoxications. Ziram and ferbam are the zinc and the iron salts respectively of dimethyl-dithiocarbamic acid (Figure 20.44). They are widely used as selective fungicides in agriculture. Pyrithione (1 -hydroxy-2(l//)-pyridinethione), as its zinc salt is used in dermatology as antiseborrheic. 

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