Iron in lipoxygenase

Pistorius, E.K. and Axelrod, B. (1976). Evidence for partidpation of iron in lipoxygenase reaction from optical and esr studies. J. Biol. Chem. 251, 7144-7148. 

In the third example, no evidence has been obtained, despite serious effort [56], for direct interaction of oxygen with the ferrous iron in lipoxygenase, but NO forms a complex with a pH-dependent Kd in the range 10-95 pM [49]. Instead, the lipoxygenase iron-NO complex (Figure 15) could be viewed as a model of an intermediate in the catalytic cycle ... 

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