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Iron compounds carbon-centered radicals

The mechanism of action for such peroxidic compounds involves a reductive activation by iron in haem, released as a result of hemoglobin digestion by Plasmodium. This irreversible redox reaction affords carbon-centered free radicals causing the alkylation of haem and of proteins. One such protein (the sarcoplasmic-endoplasmic reticulum ATPase PfATP6) appears to be critical for parasite survival, and there is no indication for resistance by the parasite. However, treatment is expensive and recrudescence of malaria occurs often. Moreover, it was found that at high doses such compounds are neurotoxic. [Pg.249]

See other pages where Iron compounds carbon-centered radicals is mentioned: [Pg.106]    [Pg.139]    [Pg.253]    [Pg.3531]    [Pg.230]    [Pg.519]    [Pg.12]    [Pg.98]    [Pg.68]    [Pg.59]    [Pg.31]    [Pg.1919]    [Pg.313]    [Pg.332]    [Pg.194]    [Pg.1918]    [Pg.10]    [Pg.28]    [Pg.7]   
See also in sourсe #XX -- [ Pg.1309 ]



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Carbon centers

Carbon radicals

Carbon-centered

Carbonate radical

Centered Radicals

Iron carbonate

Iron center

Iron compounds

Iron-carbon

Radical centers

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