Ir-Catalyzed Arylative Cyclization of Alkynones with Arylboronic Acid

Ir-Catalyzed Arylative Cyclization of Alkynones with Arylboronic Acid 

In this reaction, 1,4-metal migration by the Ir and aryl-H induced the C-H activation during the reaction. Organic transformations exploiting 1,4-metal migrations are also known for other metals such as Pd, Rh, Pt, Ni, and Co. 

N-Heterocyclization of Aminoalcohol by Ir Catalyst with a Triazolyl-diyIidene Ligand 

Synthesis of Indoles from Aminoalcohol and Alkynyl Alcohols by Ir-Pt Catalyst 

Peris and coworkers reported on a Ir/P-bimetallic complex having a 1,2,4-trimethyltriazolylidene ligand act as an efficient catalyst for the tandem oxidative cyclization of 2-(orf/zo-aminopheny)ethanol to afford indole derivatives [164]. In a typical example, 2-(ort/zo-aminophenyl)ethanol (1 equiv.) was reacted in the 

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Lam and coworkers reported that the Ir-catalyzed arylative cyclization of alkynone with arylboronic acid afforded cyclic products [162]. Here, lequiv. of alkynone was reacted with phenylboronic acid (l.Sequiv.) with a catalytic amount of [IrCl2(cod)2] (1.5mol%) and KF (l.Sequiv.) (to act as a base) and lerl-butanol (1.5 equiv.) in toluene at 65 °C and provided the tricyclic compound through arylative cyclization in 72% yield along with the 2 1 adduct in 27% yield (Scheme 11.16). 

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