Ipomoea hildebrandtii

The detection of cycloclavine (11 cieHi8N2 mp 166° [a]D +63° in chloroform) in the seeds of plants of the Convolvulacea family was surprising. In Ipomoea hildebrandtii Vatke it occurs in quantities up to 0.2%, accompanied by traces of festuclavine (14). 

Cycloclavine (30), from Ipomoea hildebrandtii, contains a cyclopropane ring, as established by an Z-ray analysis of its methobromide salt. The rugulovasines A and B (31) are optical isomers from Penicillium concavo-rugulosum. Their structures are supported by an analysis of their n.m.r. spectra and by the cooccurrence of chanoclavine in the same culture. 

A new alkaloid cvcloclavine. Q(14) containing a three-membered ring was isolated from Ipomoea hildebrandtii. A novel procedure for the determination of dissociation constants of ergot alkaloids was reported. 

Cycloclavine, an isomer of agroclavine as well as a dehydrogenated derivative of festuclavine (Fig. 4.4), a unique metabolite of Ipomoea hildebrandtii Vatke (Stauffacher et al. 1969)... 

Stauffacher, D., Niklaus, P., Tscherter, H., Weber, H.P. and Hofmann, A. (1969) Cycloclavin, ein neues alkaloid aus Ipomoea hildebrandtii Vatke—71 Mutterkornalkaloide. Tetrahedron, 25, 5879-5887. 

G.Klotz) Meeuse Genus Ipomoea Section not determined I. hildebrandtii Vatke I. jaegeri Pilg. 

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