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Iothalamate excretion

Most contrast agents elicit nephrotoxicity because they are primarily excreted by the kidneys. However, when administered in small doses, they constitute a rich source of GFR markers. The two major classes of contrast agents that are finding clinical utility as GFR markers are iodinated aromatic compounds and metal complexes. lodinated aromatics such as iohexol and iothalamate (Fig. 13) are commonly used as contrast agents for computed tomography (GT). They also have pharmacokinetics similar to inulin and hence are useful indicators of renal status [215]. The iodinated molecules used for GFR measurements consist of a triiodo-benzene core and hydrophilic groups to enhance solubility in aqueous medium. [Pg.56]

Urinary excretion is the principal means of elimination for diatrizoate, iothalamate, met-rizoate, metrizamide, and other urographic agents (688, 767, 782, 783). Diatrizoate, iothalamate, and metrizamide were excreted in the urine of the rabbit to the extent of more than 80% 24 h after injection (768,783-785). The total recovery including the amount excreted in feces 96 h after injection was about 91.5% of the dose for metrizamide, 93.8% for diatrizoate, and 86.0%for iothalamate (782). [Pg.563]

Patients undergoing screening for participation in the African-American Study of Kidney Disease and Hypertension were evaluated for kidney function based on an estimated CLcr compared with the simultaneous CLcr and I-iothalamate, and 24-hour CLcr- The simultaneous CLcr provided the best estimate of GFR. The CG method was the preferred method for estimation of GFR, based on performance and ease of use. This method was noted to underestimate the GFR by 9%, perhaps because of the increased excretion rate of creatinine by black patients. ... [Pg.772]


See other pages where Iothalamate excretion is mentioned: [Pg.469]    [Pg.60]    [Pg.178]    [Pg.16]    [Pg.37]    [Pg.436]    [Pg.81]    [Pg.517]    [Pg.536]    [Pg.557]    [Pg.561]    [Pg.562]    [Pg.576]    [Pg.769]    [Pg.295]    [Pg.97]   
See also in sourсe #XX -- [ Pg.4 , Pg.5 , Pg.62 ]

See also in sourсe #XX -- [ Pg.562 , Pg.563 , Pg.565 ]




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