Ion suppression chromatography

Tactics for separating ionic compounds Reverse phase for ionic compounds Ion suppression chromatography Paired-ion chromatography... [Pg.131]

Ion-suppressed chromatography, which means the analysis of acidic analytes imder low pH conditiorrs, thereby reducing the protolysis. The mode can be itttfavoitrable for ESI-MS, which in principle is based on the formation of preformed iotts in solution. [Pg.12]

With ion-suppression chromatography, the ionic character of a weakly acidic or basic analyte is neutralized or suppressed through modification of the mobile phase pH. By neutralizing its ionic group, the solute is less polar and... [Pg.143]

System 11 Amine adsorption/ion suppression chromatography on Micropak AX-5 with UV monitoring (200 nm) at room temperature acetonitrile/water/0.25 M sodium dihydrogenphosphate (72 18 6, v/v/v) running time 21-24 min [283]. [Pg.272]

Ion-suppression chromatography is used for the separation of weak acids and bases by reversed-phase chromatography [296-299]. The pH of the mobile phase is generally selected to either optimize the band spacing of a series of ionizable substances with different dissociation constants or set to a value to completely inhibit the dissociation of all ionizable compounds. Neutral and ionic substances can be separated simultaneously... [Pg.316]

Big Chemical Encyclopedia