Ion Pair Absorption of Ionized Drugs—Fact or Fiction

7 SUMMARY OF CHARGED-SPECIES PARTITIONING IN OCTANOL-WATER 

Scherrer observed [280,281], as have others [161,162,275], that for a large number of ordinary charged species partitioning into octanol in the presence of aqueous solutions containing 0.15 M KC1 or NaCl, weak-acid salts have values of diff(k)g PN ) equal to 4, and that weak-base salts have cliff values equal to 3. These are helpful numbers to keep in mind when predicting the values of log P1 when log PN is known. 

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ION PAIR ABSORPTION OF IONIZED DRUGS—FACT OR FICTION 53... 

Jonkman, J. H. G. Hunt, C. A., Ion pair absorption of ionized drugs—fact or fiction ... 

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