Iohexol adverse reactions

The incidence of late adverse reactions to the iso-osmo-lar agent iodixanol has also been investigated in a retrospective comparison with the non-ionic monomer iohexol. Reactions after 3075 injections were reviewed. Patients were sent a written questionnaire to find out about the incidence of any acute or delayed reactions. Those who developed reactions were interviewed by telephone and specific second questionnaires were administered. The incidence of adverse reactions was low (2% for late adverse reactions and 2.3% for acute reactions). There was no significant difference in the incidence of acute or delayed adverse reactions to iohexol and iodixanol and there were no serious reactions (32). 

Delayed reactions are generally benign, but not always. In a Japanese study, the incidence of delayed reactions was investigated in 6764 patients who received the low-osmolar non-ionic contrast medium iohexol intravenously (33). Delayed reactions (rash, pruritus, nausea, vomiting, fever, headache, and others) occurred in 192 patients (2.8%). There were no severe delayed reactions. A history of allergy and hay fever were risk factors for delayed adverse reactions. 

Munechika H, Hiramatsu Y, Kudo S, Sugimura K, Hamada C, Yamaguchi K, Katayama H. Delayed adverse reactions to nonionic contrast medium (iohexol) in IV use multicentric study. Acad Radiol 2002 9(Suppl 1) S69-71. 

Glover JR, Thomas BM. Case report severe adverse reaction to oral iohexol. Chn Radiol 1991 44(2) 137-8. 

There was no difference in the incidence of adverse effects between iotrolan 320 and iohexol 350 in cardiac angiography for ischemic heart disease in 120 patients (22). There were no serious adverse events. One patient developed mild urticaria after iotrolan. Five patients in each group had mild unspecified delayed reactions. 

Acute reactions All adverse events occurring within 1 hour of administration of intravenous contrast media were prospectively compared in 8931 patients who were randomly assigned to one of five low-osmolar non-ionic contrast media iomeprol 300 mgl/ml, iopamidol 300mgl/ml, iohexol 300mgl/ml, iopromide 300mgl/ml, and ioversol 320mgl/ml [I "]. 

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