4- Iodopyrimidine, coupling with alkenes

Further papers have appeared on the coupling of halogeno-pyrimidines, in particular iodopyrimidines, and terminal alkenes and alkynes. For example, palladium (II) acetate with a... 

Pyridopyrimidines of the [2,3-d], [3,4-d] and [4.,3-d] types may be prepared by reactions involving the cross-coupling of halogenopyrimidines with alkenes and alkynes. For example, 4,-amino-5-iodopyrimidines (298) with S-unsaturated carboxylic esters followed by ring-closure give the pyrido[2,3-d]pyrimidines (299)... 

---