Iodophosphine boranes

With this strategy, tert-butylmethylphenylphosphine borane and PAMP-BH3 were obtained, although the latter presented low optical purity (41% ee) due to racemisation in the decarboxylation step, which had been performed in xylene at 130 °C for 1 h. The menthyl ester intermediate 60, for R = o-An, was also reduced to the alcohol, which was mesylated and iodinated affording the (I-iodophosphine borane 62 in 62% combined yield. This compound was reductively dimerised by activated copper to diphosphine borane 63 (64% yield), which is similar to DiPAMP but with a butyl bridge. 

Table 5.5 Substitution reactions in bromo- or iodophosphine boranes 27 (Scheme 5.12).

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See also in sourсe #XX -- [ ]

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