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Iodobenzoic methyl ester

The first involved cyclisation of 3, 5 -dimethoxy-3-bromopropion-anilide to the carbostyril (XVII), which was condensed with 2-iodobenzoic acid and the product cyclised to (XVIIIa). The methyl ester (XVIIIb) was demethylated with boron trichloride to (XVIIIc), which gave (XVIIId) on... [Pg.16]

The design of a novel series of cycUn-dependent kinase (CDK) inhibitors with a macrocyclic quinoxaline-2-one 208 is reported (Kawanishi et al. 2006), where 208 was synthesized as shown in Scheme 5.50. The deprotonation of the fluorine-adjacent position of l-fluoro-2-iodobenzene 209, with LDA, followed by the carbon dioxide trapping and then esterification of the carboxylic acid, led to methyl 2-fluoro-3-iodobenzoate. The iodomagnesium exchange of methyl 2-fluoro-3-iodobenzoate according to Knochel s procedure (Knochel et al. 2003) followed by chloroglyoxylic acid ethyl ester resulted in ketoester 210, which was coupled with 3-[(tert-bulyldimethylsilyl)oxy]benzene-1,2-diamine to... [Pg.325]

See other pages where Iodobenzoic methyl ester is mentioned: [Pg.40]    [Pg.191]    [Pg.179]    [Pg.283]    [Pg.324]    [Pg.277]    [Pg.40]    [Pg.199]    [Pg.376]    [Pg.159]    [Pg.160]    [Pg.347]    [Pg.444]    [Pg.514]    [Pg.136]    [Pg.117]    [Pg.171]    [Pg.102]    [Pg.115]   


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2- Iodobenzoic

Iodobenzoate

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