Iodoaryl alkenyl azides

Azides are highly valuable radical acceptors that form nitrogen-centered radicals after addition onto them, as in the case of the transformation of 31 into 32. This reaction opens new possibilities for making pyrrolidines. Murphy, for instance, disclosed the synthesis of ( )-horsfihne and ( )-coerulescine by tandem cyclization of iodoaryl alkenyl azides such as 29 [42]. By the same strategy and using precursor 33, formal syntheses of ( )-vindohne [43] and ( )-aspidospermidine [44] have been rendered possible (Scheme 10). 

Lizos DE, Murphy JA (2003) Concise synthesis of (-1-/—)-horsfiline and (-t-/—)-coerulescine by tandem cyciisation of iodoaryl alkenyl azides. Org Biomol Chem 1 117-122... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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