Butane, 2-Iodo-2-methyl

The El mechanism generally occurs when an alkyl halide is dissolved in protic solvent where the solvent can act as a non-basic nucleophile. These are the same conditions for the SN1 reaction and so both these reactions generally take place simultaneously forming a mixture of products. For example, the El mechanism is the reaction of 2-iodo-2-methyl-butane with methanol ... 

Iodo-2-methyl-butane (CH3)2CIC2H5 54.3 227.0 Correlation 2003KRO/TUM... 

C5H9I 3-iodo-trans-2-pentene 66688-60-6 17.481 126.472 1.2 5341 C5H10CI2 1,2-dichloro-2-methyl butane 23010-04-0 17.170 131.813 1,2... 

C5H9I cis-1 -iodo-2-methyl-1 -butene 52812-57-4 17.481 126.472 1,2 5346 C5H10CI2 2,2-dichloro-3-methyl butane 17773-66-9 17.466 129.394 1,2... 

Is this correct It depends on how long the reaction is allowed to proceed. If the reaction is stopped after 1 or 2 hours, the answer is, indeed, no reaction. If the reaction is heated for several days or several weeks, two different products may be observed 2-iodo-2-methylbutane and 2-ethoxy-2-methyl-butane. Both products arise by an SnI process. Given sufficient time, slow ionization to a tertiary carbocation is followed by trapping with iodide ion or with ethanol. This process is known as solvolysis (see Chapter 11, Section 11.6). This contradicts the assumption that ionization can only occur in water because it is an assumption, as pointed out in the earlier section and thus not always correct. Indeed, ionization occurs in protic solvents such as ethanol, but it is slow relative to ionization in water. If 2-bromobutane is heated with KI in ethanol, the Sn2 product (Chapter 11, Section 11.2) is formed, indicating that the Sn2 reaction is much faster than the very slow ionization reaction in ethanol. 

ITS DIMER, 52, 77 Methyl D-Norandrost-5-en-3 g-ol-166-carboxylate, 52, 56 (S)- (-) - 3-Methylpentanal, from 2-lithio-l,3,5-trithiane and (S)-(+)-l-iodo-2-methy 1-butane, 51, 43... 

A soln. of methyl vinyl ketone and p-toluenesulfonyl iodide in dichloromethane stirred for ca. 1 day at room temp. - 3-iodo-4-(/ -tolylsulfonyl)butan-2-one (Y 87%), in dichloromethane treated slowly with a soln. of NEt, in the same solvent at 0° with stirring, and worked up after 1 h at room temp. - (E)-4-(/>-tolylsulfonyl)but-3-en-2-one (Y 95%). F.e. (incl. aldehyde, ester, acid, amide and nitrile analogs), also with in 5/m-generated / -toluenesulfonyl iodide (from Na-/ -toluenesulfinate and L), s. C. Najera et al., J. Chem. Soc. Perkin Trans. I 1988, 1029-32. 

The most known designer drugs are carphedone 4-chloro-2,5-dimethoxyphenethylamine (2C-C) i 5-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yM-methylpiperazine-l-carboxylate (zopiclone or Z-drug) 4-(N,N-dimethylamino sulfonyl)-7-fluoro-2,l,3-benzoxadiazole (DBD-F) dimethyltryptamine (DMTA) diphenydramine 4-ethyl-2,5-dimethoxyphenethylamine (2C-E) 4-ethylthio-2,5-dimethoxyphenethylamine (2C-T-2) 4-fluoroamphetamine (4-FMP) indan-2-amine 4-iodo-2,5-dimethoxyphenethylamine (2C-I) 1 -(4-iodo-2,5-dimethoxyphenyl)propan-2-amine (DOI) 4-isopropylthio-2,5-dimethyoxyphenethylamine (2C-T-4) meperidine 2-methylamino-l-(3,4-methylenedioxyphenyl)butan-l-one (Bk-MBDB) l-(3,4-methylenedioxybenzyl)piperazine (MDBP) 1 -(3,4-methylenedioxyphenyl)butan-2-amine (BDB) N-methyl-3,4-methylenedioxymethamphetamine (MMDA-2) N-methyl-1 -(3,4-methylenedioxyphenyl)butan-2-amine (HMDMA) N-methyl-l-(3,4-methylenedioxyphenyl)butan-3-amine (HMDMA) methylphenidate 4-methoxymethamphetamine (PMMA) l-(4-methoxyphenyl)piperazine (4-MPP) 2-(6-methyl-2-p-tolylimidazol[l,2-9]pyridine-3-yl)acetamide (zolpidem) normeperidine 4-phenylbutylamine (4-PBA) 3-phenyl-1-peopyTamine (3-PPA) and 2,4,6-trimethoxyamphetamine (TMA-6). 

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