7 -Iodo- 8-hydroxyquinoline - 5 - sulfonic

Certain halogen derivatives of 8-hydroxyquinoline have a record of therapeutic efficacy in the treatment of cutaneous fungus infections and also of amebic dysentery. Among these are 5-chloro-7-iodo-8-quinolinol [130-26-7] (iodochlorhydroxyquin, Vioform), 5,7-diiodo-8-hydroxyquinoline [83-73-8] (diiodohydroxyquin), and sodium 7-iodo-8-hydroxyquinoline-5-sulfonate [885-04-1] (chiniofon) (196—198). 

Iodo-8-hydroxyquinoline-5-sulfonic acid (ferron) (C H O NIS), H L (Other... 

Substitution at polynuclear aqua-ions is often much slower than at the respective parent mononuclear aqua-ions, as has been demonstrated for, e.g., aluminum(III), iron(III), zirconium(IV), and hafnium(IV). A further example has been provided by aluminum, where the Al,3 polynuclear oxo-aqua-species takes several months to equilibrate with lactate. Very different rates of complex formation are used to sort out speciation in multicomponent polynuclear/mononuclear aqua-cation systems. The problems involved in this approach are well illustrated by a Al NMR study of the numerous reaction pathways in the Al " /ferron [ferron = 7-iodo-8-hydroxyquinoline-5-sulfonic acid, (18)] reaction. The slowness of reaction of polynuclear species can cause difficulties in the determination of total metal content, e.g., of aluminum by ferron or Alizarin S (19), in natural waters. In certain situations these... 

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