5 Iodo anthranilic acid

Iodo-3-nitrobenzoic acid has been prepared by the diazo-tization of 3-nitro-anthranilic acid.2... 

The stability constants of uranyl amino- and mercapto-acid complexes have been determined. Among the acids investigated were cysteine, methionine, P-alanine, anthranilic acid, serine, threonine, and JV-ac tylglycine. Stability constants of a series of chloro-, bromo-, iodo-, and nitro-substituted salicylic acid and of o-pyrocatechinic, y-resorcylic, and gentisic acids complexes of UOj" have been measured 1 1 and 1 2 species were identified. It was observed that there was a distinct dependence of stability constant on the charge of the central metal atom in UO ", NpO, and Pu " tropolonato complexes. ... 

Proquinazid can be prepared starting from 5-iodoanthranilic acid (Scheme 22.3) [27, 32, 33]. Cyclization with n-propyl isothiocyanate affords 2,3-dihydro-6-iodo-3-propyl-2-thioxo-4(lH)-quinazolinone. Alternatively, this key intermediate can be obtained by reaction of an appropriate anthranilate with thiophosgene and n-propylamine. Subsequent introduction of the propoxy substituent via a methyl-ation displacement sequence concludes the synthesis. 

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