Iodine-121: positron emission tomography

Almeida, P., Ribeiro, M. J., Bottlaender, M. et al. Absolute quantitation of iodine-123 epidepride kinetics using single-photon emission tomography comparison with carbon-11 epidepride and positron emission tomography. Eur. J. Nucl. Med. 26 1580-1588,1999. 

Glaser, M., Collingridge, D.R., Aboagye, E.O., Bouchier-Hayes, L., Hutchinson, O.C., Martin, S., Price, P., Brady, F., and Luthra, S.K. Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography. Appl. Radiat. Isot., 58 55-62, 2003. 

Robinson M K, Doss M, Shaller C, et al. (2005). Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody. Cancer Res. 65 1471-1478. 

However, a body of evidence is being accumulated that if a halogen, such as a bromine or an iodine atom, is replaced by a beta-fluoroethyl group, the electronic and polar properties of the drug can be pretty much the same. So, what psychedelics have a bromo or an iodo group Obviously, DOB and DOI. Thus, DOEF is a natural candidate for fluorine-18 positron emission tomography, and also a natural candidate for clinical trials. And, voila, it is an active material. 

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