Iodine , active catalytic species, generation from

Isoxazoles display a range of biological activities, such as anti-inflammatory, antimicrobial, anticancer, and antinociceptive, that justify a constant effort in the development of new synthetic strategies. New syntheses of isoxazoles 1 and isQxazolines 2 via 1,3-dipolar cycloaddition (1,3-DC) of alkynes and alkenes with nitrile oxides were described (130L4010). The 1,3-dipoles were generated by oxidation of aldoximes catalyzed with hypervalent iodine species formed in situ from catalytic iodoarene and oxone as a terminal oxidant, in the presence of hexafluoroisopropanol (HFIP) in aqueous methanol solution. 

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