Inverting glycosyl hydrolases, mechanism

The recent burst of reported GT structures has shed light on their substrate binding and catalytic mechanisms. GTs are thought to use mechanistic strategies that directly parallel those used by the well characterised glycosyl hydrolases. However, while the mechanism of inverting GTs appears to be widely accepted, the mechanism of retaining enzymes remains a topic of considerable debate. These aspects will be discussed later in the chapter. 

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