Inverse Agonism at Cannabinoid Receptors

There is good evidence that when administered by itself in vivo or in vitro, SR141716A is capable of producing inverse cannabimimetic effects, i.e. effects 

SR144528 has greater inverse intrinsic activity than AM630. If this interpretation of the data is valid, it is of course an indication that just as the intrinsic activities of CBi and CB2 receptor agonists can vary from compound to compound, so too the (inverse) intrinsic activities of cannabinoid receptor inverse agonists will not be the same for all such ligands. 

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Pertwee RG (2001) Cannabinoid receptors and pain. Prog Neurobiol 63 569-611 Pertwee RG (2003) Inverse agonism at cannabinoid receptors. In IJzerman AP (ed) Inverse... 

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