Invasion mechanisms

Obesity is a difficult condition to treat. Dietary restriction of caloric intake is the first line therapy and is optimally combined with an exercise program to promote loss of fat relative to lean body mass (17). For the grossly obese (BMI > 40), invasive mechanical measures such as jaw wiring, gastric banding, and gastric by-pass have been attempted with at least limited success (18). 

Noninvasive positive-pressure ventilation (NPPV) provides ventilatory support with oxygen and pressurized airflow using a face or nasal mask with a tight seal but without endotracheal intubation. In patients with acute respiratory failure due to COPD exacerbations, NPPV was associated with lower mortality, lower intubation rates, shorter hospital stays, and greater improvements in serum pH in 1 hour compared with usual care. Use of NPPV reduces the complications that often arise with invasive mechanical ventilation. NPPV is not appropriate for patients with altered mental status, severe acidosis, respiratory arrest, or cardiovascular instability. 

Friis LM, Pin C, Pearson BM, Wells JM. In vitro cell culture methods for investigating Campylobacter invasion mechanisms. J Microbiol Methods 2005 May 61(2) 145-160. Erratum in J Microbiol Methods 2005 Oct 63(1) 104. 

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