Introduction of the tryptamine side-chain

3-(2-Nitroethenyl)indoles can be prepared by reaction of an indole with 2-(dimethylamino)-l-nitroethene in TFA[10]. 3-(2-Nitroethenyl)indolcs can 

Fntry Indole substituent Amine Reduct ant Yield (%) Ref 

LiAlH4, AIH3 has been used for reduction[9]. Stepwise reduction, first to the 

Tryptamines can also be prepared from gramine via indole-3-acetonitriles. This procedure was found advanta ous for C-ha o tryptamines[9]. 

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